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The role of glutathione S-transferase P1-1 (GSTP1-1) in the cellular detoxification of cisplatin
Cells expressing elevated levels of allelic variants of human GSTP1 and/or efflux transporters, MRP 1 or 2, were used to evaluate the role of GSTP1-1 in cisplatin resistance. These studies revealed that GSTP1-1 confers low-level resistance (1.4–1.7-fold) to cisplatin-induced cytotoxicity in MCF7 cel...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587032/ https://ncbi.nlm.nih.gov/pubmed/18852128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0250 |
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