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Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas
Glycoprotein NMB (GPNMB), a transmembrane glycoprotein highly expressed in high-grade gliomas (HGGs), is an attractive target in cancer immunotherapy. We isolated a GPNMB-specific scFv clone, G49, from a human synthetic phage-display library. To obtain mutant single-chain variable-fragment antibodie...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024457/ https://ncbi.nlm.nih.gov/pubmed/20824708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25645 |
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