Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas

Glycoprotein NMB (GPNMB), a transmembrane glycoprotein highly expressed in high-grade gliomas (HGGs), is an attractive target in cancer immunotherapy. We isolated a GPNMB-specific scFv clone, G49, from a human synthetic phage-display library. To obtain mutant single-chain variable-fragment antibodie...

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Autores principales: Kuan, Chien-Tsun, Wakiya, Kenji, Keir, Stephen T., Li, Jianjun, Herndon, James E., Pastan, Ira, Bigner, Darell D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024457/
https://ncbi.nlm.nih.gov/pubmed/20824708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25645
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