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EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells

PURPOSE: Immunotoxins as anti-cancer therapeutics have several potential advantages over conventional agents including a high specificity, extraordinary potency, and a lack of an identified mechanism for resistance. It has been clearly demonstrated that Pseudomonas-based immunotoxins have a direct c...

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Detalhes bibliográficos
Main Authors: Ochiai, Hidenobu, Archer, Gary E., Herndon, James E., Kuan, Chien-Tsun, Mitchell, Duane A., Bigner, Darell D., Pastan, Ira H., Sampson, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846815/
https://ncbi.nlm.nih.gov/pubmed/17634939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-007-0363-7
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