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Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma
Bispecific antibodies (bscAbs), particularly those of the bispecific T-cell engager (BiTE) subclass, have been shown to effectively redirect T cells against cancer. Previous efforts to target antigens expressed in both tumors and normal tissues have produced significant toxicity, however. Moreover,...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538214/ https://ncbi.nlm.nih.gov/pubmed/23248284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219817110 |
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