Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma

Bispecific antibodies (bscAbs), particularly those of the bispecific T-cell engager (BiTE) subclass, have been shown to effectively redirect T cells against cancer. Previous efforts to target antigens expressed in both tumors and normal tissues have produced significant toxicity, however. Moreover,...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Choi, Bryan D., Kuan, Chien-Tsun, Cai, Mingqing, Archer, Gary E., Mitchell, Duane A., Gedeon, Patrick C., Sanchez-Perez, Luis, Pastan, Ira, Bigner, Darell D., Sampson, John H.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538214/
https://ncbi.nlm.nih.gov/pubmed/23248284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219817110
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares