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Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody
Regulatory T cells (Tregs) play a central role in in tumor escape from immunosurveillance. We report that a bispecific T-cell engager (BiTE) targeting a mutated form of the epidermal growth factor receptor, i.e., EGFRvIII, potently redirects Tregs to kill glioblastoma through the granzyme-perforin p...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3891636/ https://ncbi.nlm.nih.gov/pubmed/24475376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.26757 |
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