Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody

Regulatory T cells (Tregs) play a central role in in tumor escape from immunosurveillance. We report that a bispecific T-cell engager (BiTE) targeting a mutated form of the epidermal growth factor receptor, i.e., EGFRvIII, potently redirects Tregs to kill glioblastoma through the granzyme-perforin p...

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Bibliographic Details
Main Authors: Choi, Bryan D, Gedeon, Patrick C, Sanchez-Perez, Luis, Bigner, Darell D, Sampson, John H
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891636/
https://ncbi.nlm.nih.gov/pubmed/24475376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.26757
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