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EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity

EGFR and its constitutively activated variant EGFRvIII are linked to glioblastoma resistance to therapy, the mechanisms underlying this association, however, are still unclear. We report that in glioblastoma, EGFR/EGFRvIII paradoxically co-expresses with p53-upregulated modulator of apoptosis (PUMA)...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Zhu, Hu, Cao, Xinyu, Ali-Osman, Francis, Keir, Stephen, Lo, Hui-Wen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875288/
https://ncbi.nlm.nih.gov/pubmed/20153921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2010.01.028
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