An EGFR wild type-EGFRvIII-HB-EGF feed forward loop regulates the activation of EGFRvIII

EGFRvIII is a key oncogene in glioblastoma (GBM). EGFRvIII results from an in frame deletion in the extracellular domain of EGFR, does not bind ligand, and is thought to be constitutively active. While EGFRvIII dimerization is known to activate EGFRvIII, the factors that drive EGFRvIII dimerization...

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主要な著者: Li, Li, Chakraborty, Sharmistha, Yang, Chin-Rang, Hatanpaa, Kimmo J., Cipher, Daisha J., Puliyappadamba, Vineshkumar Thidil, Rehman, Alizeh, Jiwani, Ameena J., Mickey, Bruce, Madden, Christopher, Raisanen, Jack, Burma, Sandeep, Saha, Debabrata, Wang, Zhixiang, Pingle, Sandeep C., Kesari, Santosh, Boothman, David A., Habib, Amyn A.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969863/
https://ncbi.nlm.nih.gov/pubmed/24077285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.400
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