An EGFR wild type-EGFRvIII-HB-EGF feed forward loop regulates the activation of EGFRvIII

EGFRvIII is a key oncogene in glioblastoma (GBM). EGFRvIII results from an in frame deletion in the extracellular domain of EGFR, does not bind ligand, and is thought to be constitutively active. While EGFRvIII dimerization is known to activate EGFRvIII, the factors that drive EGFRvIII dimerization...

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Bibliografski detalji
Glavni autori: Li, Li, Chakraborty, Sharmistha, Yang, Chin-Rang, Hatanpaa, Kimmo J., Cipher, Daisha J., Puliyappadamba, Vineshkumar Thidil, Rehman, Alizeh, Jiwani, Ameena J., Mickey, Bruce, Madden, Christopher, Raisanen, Jack, Burma, Sandeep, Saha, Debabrata, Wang, Zhixiang, Pingle, Sandeep C., Kesari, Santosh, Boothman, David A., Habib, Amyn A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969863/
https://ncbi.nlm.nih.gov/pubmed/24077285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.400
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