Opposing effect of EGFRwt on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch

RIP1 is a central mediator of cell death in cell stress, but can also mediate cell survival by activating NF-κB. Here, we show that RIP1 is a switch in EGFR signaling. EGFRvIII is an oncogenic mutant that does not bind ligand and is co-expressed with EGFRwt in glioblastoma (GBM). EGFRvIII recruits u...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Puliyappadamba, Vineshkumar Thidil, Chakraborty, Sharmistha, Chauncey, Sandili S., Li, Li, Hatanpaa, Kimmo J., Mickey, Bruce, Noorani, Shayan, Shu, Hui-Kuo G., Burma, Sandeep, Boothman, David A., Habib, Amyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780989/
https://ncbi.nlm.nih.gov/pubmed/23972990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.025
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados