Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations

BACKGROUND: D2C7-IT is a novel immunotoxin (IT) targeting wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFR variant III (EGFRvIII) proteins in glioblastoma. In addition to inherent tumoricidal activity, immunotoxins induce secondary immune responses through the activation of T cell...

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Detalles Bibliográficos
Publicado en:J Immunother Cancer
Main Authors: Chandramohan, Vidyalakshmi, Bao, Xuhui, Yu, Xin, Parker, Scott, McDowall, Charlotte, Yu, Yen-Rei, Healy, Patrick, Desjardins, Annick, Gunn, Michael D., Gromeier, Matthias, Nair, Smita K., Pastan, Ira H., Bigner, Darell D.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542114/
https://ncbi.nlm.nih.gov/pubmed/31142380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0614-0
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