Construction of an immunotoxin, D2C7-(scdsFv)-PE38KDEL, targeting EGFRwt and EGFRvIII for brain tumor therapy

PURPOSE: The epidermal growth factor receptor gene (EGFR) is most frequently amplified and overexpressed, along with its deletion mutant, EGFRvIII, in glioblastoma. We tested the preclinical efficacy of the recombinant immunotoxin, D2C7-(scdsFv)-PE38KDEL, which is reactive with a 55-amino acid (AA)...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Chandramohan, Vidyalakshmi, Bao, Xuhui, Keir, Stephen T., Pegram, Charles N., Szafranski, Scott E., Piao, Hailan, Wikstrand, Carol J., McLendon, Roger E., Kuan, Chien-Tsun, Pastan, Ira H., Bigner, Darell D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766439/
https://ncbi.nlm.nih.gov/pubmed/23857604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3891
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados