Production and quality control assessment of a GLP-grade immunotoxin, D2C7-(scdsFv)-PE38KDEL, for a Phase I/II clinical trial

D2C7-(scdsFv)-PE38KDEL (D2C7-IT) is a novel recombinant Pseudomonas exotoxin A-based immunotoxin (IT), targeting both wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFR variant III (EGFRvIII) proteins overexpressed in glioblastomas. Initial preclinical testing demonstrated the anti-...

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Bibliographic Details
Published in:Appl Microbiol Biotechnol
Main Authors: Chandramohan, Vidyalakshmi, Pegram, Charles N., Piao, Hailan, Szafranski, Scott E., Kuan, Chien-Tsun, Pastan, Ira H., Bigner, Darell D.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354975/
https://ncbi.nlm.nih.gov/pubmed/28013405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-016-8063-x
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