Construction of an immunotoxin, D2C7-(scdsFv)-PE38KDEL, targeting EGFRwt and EGFRvIII for brain tumor therapy

PURPOSE: The epidermal growth factor receptor gene (EGFR) is most frequently amplified and overexpressed, along with its deletion mutant, EGFRvIII, in glioblastoma. We tested the preclinical efficacy of the recombinant immunotoxin, D2C7-(scdsFv)-PE38KDEL, which is reactive with a 55-amino acid (AA)...

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Hoofdauteurs: Chandramohan, Vidyalakshmi, Bao, Xuhui, Keir, Stephen T., Pegram, Charles N., Szafranski, Scott E., Piao, Hailan, Wikstrand, Carol J., McLendon, Roger E., Kuan, Chien-Tsun, Pastan, Ira H., Bigner, Darell D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766439/
https://ncbi.nlm.nih.gov/pubmed/23857604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3891
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