Construction of an immunotoxin, D2C7-(scdsFv)-PE38KDEL, targeting EGFRwt and EGFRvIII for brain tumor therapy

PURPOSE: The epidermal growth factor receptor gene (EGFR) is most frequently amplified and overexpressed, along with its deletion mutant, EGFRvIII, in glioblastoma. We tested the preclinical efficacy of the recombinant immunotoxin, D2C7-(scdsFv)-PE38KDEL, which is reactive with a 55-amino acid (AA)...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chandramohan, Vidyalakshmi, Bao, Xuhui, Keir, Stephen T., Pegram, Charles N., Szafranski, Scott E., Piao, Hailan, Wikstrand, Carol J., McLendon, Roger E., Kuan, Chien-Tsun, Pastan, Ira H., Bigner, Darell D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766439/
https://ncbi.nlm.nih.gov/pubmed/23857604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3891
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak