EGFR wild type antagonizes EGFRvIII-mediated activation of Met in glioblastoma

Epidermal growth factor receptor (EGFR)vIII is the most common EGFR mutant found in glioblastoma (GBM). EGFRvIII does not bind ligand, is highly oncogenic and is usually coexpressed with EGFR wild type (EGFRwt). EGFRvIII activates Met, and Met contributes to EGFRvIII-mediated oncogenicity and resist...

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Publicado no:Oncogene
Main Authors: Li, L, Puliyappadamba, VT, Chakraborty, S, Rehman, A, Vemireddy, V, Saha, D, Souza, RF, Hatanpaa, KJ, Koduru, P, Burma, S, Boothman, DA, Habib, AA
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4804705/
https://ncbi.nlm.nih.gov/pubmed/24362532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.534
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