EGFR wild type antagonizes EGFRvIII-mediated activation of Met in glioblastoma

Epidermal growth factor receptor (EGFR)vIII is the most common EGFR mutant found in glioblastoma (GBM). EGFRvIII does not bind ligand, is highly oncogenic and is usually coexpressed with EGFR wild type (EGFRwt). EGFRvIII activates Met, and Met contributes to EGFRvIII-mediated oncogenicity and resist...

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Bibliographic Details
Published in:	Oncogene
Main Authors:	Li, L, Puliyappadamba, VT, Chakraborty, S, Rehman, A, Vemireddy, V, Saha, D, Souza, RF, Hatanpaa, KJ, Koduru, P, Burma, S, Boothman, DA, Habib, AA
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4804705/ https://ncbi.nlm.nih.gov/pubmed/24362532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.534
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EGFR wild type antagonizes EGFRvIII-mediated activation of Met in glioblastoma

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