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EGFR wild type antagonizes EGFRvIII-mediated activation of Met in glioblastoma
Epidermal growth factor receptor (EGFR)vIII is the most common EGFR mutant found in glioblastoma (GBM). EGFRvIII does not bind ligand, is highly oncogenic and is usually coexpressed with EGFR wild type (EGFRwt). EGFRvIII activates Met, and Met contributes to EGFRvIII-mediated oncogenicity and resist...
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| Published in: | Oncogene |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4804705/ https://ncbi.nlm.nih.gov/pubmed/24362532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.534 |
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