EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

Glioblastoma multiforme (GBM) are lethal tumors that are highly resistant to ionizing radiation (IR) and chemotherapy. Here, we report on a molecular mechanism by which a key glioma-specific mutation, EGFRvIII, confers radiation resistance. Using Ink4a/Arf-deficient primary mouse astrocytes, primary...

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Detalhes bibliográficos
Main Authors: Mukherjee, Bipasha, McEllin, Brian, Camacho, Cristel V., Tomimatsu, Nozomi, Sirasanagandala, Shyam, Nannepaga, Suraj, Hatanpaa, Kimmo J., Mickey, Bruce, Madden, Christopher, Maher, Elizabeth, Boothman, David A., Furnari, Frank, Cavenee, Webster K., Bachoo, Robert M., Burma, Sandeep
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694953/
https://ncbi.nlm.nih.gov/pubmed/19435898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4853
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