EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

Glioblastoma multiforme (GBM) are lethal tumors that are highly resistant to ionizing radiation (IR) and chemotherapy. Here, we report on a molecular mechanism by which a key glioma-specific mutation, EGFRvIII, confers radiation resistance. Using Ink4a/Arf-deficient primary mouse astrocytes, primary...

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Autores principales: Mukherjee, Bipasha, McEllin, Brian, Camacho, Cristel V., Tomimatsu, Nozomi, Sirasanagandala, Shyam, Nannepaga, Suraj, Hatanpaa, Kimmo J., Mickey, Bruce, Madden, Christopher, Maher, Elizabeth, Boothman, David A., Furnari, Frank, Cavenee, Webster K., Bachoo, Robert M., Burma, Sandeep
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694953/
https://ncbi.nlm.nih.gov/pubmed/19435898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4853
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