EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

Glioblastoma multiforme (GBM) are lethal tumors that are highly resistant to ionizing radiation (IR) and chemotherapy. Here, we report on a molecular mechanism by which a key glioma-specific mutation, EGFRvIII, confers radiation resistance. Using Ink4a/Arf-deficient primary mouse astrocytes, primary...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Mukherjee, Bipasha, McEllin, Brian, Camacho, Cristel V., Tomimatsu, Nozomi, Sirasanagandala, Shyam, Nannepaga, Suraj, Hatanpaa, Kimmo J., Mickey, Bruce, Madden, Christopher, Maher, Elizabeth, Boothman, David A., Furnari, Frank, Cavenee, Webster K., Bachoo, Robert M., Burma, Sandeep
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2009
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694953/
https://ncbi.nlm.nih.gov/pubmed/19435898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4853
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