EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

Glioblastoma multiforme (GBM) are lethal tumors that are highly resistant to ionizing radiation (IR) and chemotherapy. Here, we report on a molecular mechanism by which a key glioma-specific mutation, EGFRvIII, confers radiation resistance. Using Ink4a/Arf-deficient primary mouse astrocytes, primary...

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Détails bibliographiques
Auteurs principaux: Mukherjee, Bipasha, McEllin, Brian, Camacho, Cristel V., Tomimatsu, Nozomi, Sirasanagandala, Shyam, Nannepaga, Suraj, Hatanpaa, Kimmo J., Mickey, Bruce, Madden, Christopher, Maher, Elizabeth, Boothman, David A., Furnari, Frank, Cavenee, Webster K., Bachoo, Robert M., Burma, Sandeep
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694953/
https://ncbi.nlm.nih.gov/pubmed/19435898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4853
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