Opposing effect of EGFRwt on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch

RIP1 is a central mediator of cell death in cell stress, but can also mediate cell survival by activating NF-κB. Here, we show that RIP1 is a switch in EGFR signaling. EGFRvIII is an oncogenic mutant that does not bind ligand and is co-expressed with EGFRwt in glioblastoma (GBM). EGFRvIII recruits u...

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Main Authors: Puliyappadamba, Vineshkumar Thidil, Chakraborty, Sharmistha, Chauncey, Sandili S., Li, Li, Hatanpaa, Kimmo J., Mickey, Bruce, Noorani, Shayan, Shu, Hui-Kuo G., Burma, Sandeep, Boothman, David A., Habib, Amyn A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780989/
https://ncbi.nlm.nih.gov/pubmed/23972990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.025
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