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Opposing effect of EGFRwt on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch
RIP1 is a central mediator of cell death in cell stress, but can also mediate cell survival by activating NF-κB. Here, we show that RIP1 is a switch in EGFR signaling. EGFRvIII is an oncogenic mutant that does not bind ligand and is co-expressed with EGFRwt in glioblastoma (GBM). EGFRvIII recruits u...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3780989/ https://ncbi.nlm.nih.gov/pubmed/23972990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.025 |
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