Opposing effect of EGFRwt on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch

RIP1 is a central mediator of cell death in cell stress, but can also mediate cell survival by activating NF-κB. Here, we show that RIP1 is a switch in EGFR signaling. EGFRvIII is an oncogenic mutant that does not bind ligand and is co-expressed with EGFRwt in glioblastoma (GBM). EGFRvIII recruits u...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Puliyappadamba, Vineshkumar Thidil, Chakraborty, Sharmistha, Chauncey, Sandili S., Li, Li, Hatanpaa, Kimmo J., Mickey, Bruce, Noorani, Shayan, Shu, Hui-Kuo G., Burma, Sandeep, Boothman, David A., Habib, Amyn A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780989/
https://ncbi.nlm.nih.gov/pubmed/23972990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.07.025
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky