An EGFR wild type-EGFRvIII-HB-EGF feed forward loop regulates the activation of EGFRvIII

EGFRvIII is a key oncogene in glioblastoma (GBM). EGFRvIII results from an in frame deletion in the extracellular domain of EGFR, does not bind ligand, and is thought to be constitutively active. While EGFRvIII dimerization is known to activate EGFRvIII, the factors that drive EGFRvIII dimerization...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Li, Li, Chakraborty, Sharmistha, Yang, Chin-Rang, Hatanpaa, Kimmo J., Cipher, Daisha J., Puliyappadamba, Vineshkumar Thidil, Rehman, Alizeh, Jiwani, Ameena J., Mickey, Bruce, Madden, Christopher, Raisanen, Jack, Burma, Sandeep, Saha, Debabrata, Wang, Zhixiang, Pingle, Sandeep C., Kesari, Santosh, Boothman, David A., Habib, Amyn A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969863/
https://ncbi.nlm.nih.gov/pubmed/24077285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.400
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