An EGFR wild type-EGFRvIII-HB-EGF feed forward loop regulates the activation of EGFRvIII

EGFRvIII is a key oncogene in glioblastoma (GBM). EGFRvIII results from an in frame deletion in the extracellular domain of EGFR, does not bind ligand, and is thought to be constitutively active. While EGFRvIII dimerization is known to activate EGFRvIII, the factors that drive EGFRvIII dimerization...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Li, Li, Chakraborty, Sharmistha, Yang, Chin-Rang, Hatanpaa, Kimmo J., Cipher, Daisha J., Puliyappadamba, Vineshkumar Thidil, Rehman, Alizeh, Jiwani, Ameena J., Mickey, Bruce, Madden, Christopher, Raisanen, Jack, Burma, Sandeep, Saha, Debabrata, Wang, Zhixiang, Pingle, Sandeep C., Kesari, Santosh, Boothman, David A., Habib, Amyn A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969863/
https://ncbi.nlm.nih.gov/pubmed/24077285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.400
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