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Enzyme Redesign Guided by Cancer-Derived IDH1 Mutations

Mutations in an enzyme can result in a neomorphic catalytic activity in cancers. We applied cancer-associated mutations from isocitrate dehydrogenases (IDHs) to homologous residues in the active sites of homoisocitrate dehydrogenases (HIDHs) to derive enzymes that catalyze the conversion of 2-oxoadi...

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Hlavní autoři: Reitman, Zachary J., Choi, Bryan D., Spasojevic, Ivan, Bigner, Darell D., Sampson, John H., Yan, Hai
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487689/
https://ncbi.nlm.nih.gov/pubmed/23001033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1065
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