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Enzyme Redesign Guided by Cancer-Derived IDH1 Mutations
Mutations in an enzyme can result in a neomorphic catalytic activity in cancers. We applied cancer-associated mutations from isocitrate dehydrogenases (IDHs) to homologous residues in the active sites of homoisocitrate dehydrogenases (HIDHs) to derive enzymes that catalyze the conversion of 2-oxoadi...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3487689/ https://ncbi.nlm.nih.gov/pubmed/23001033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1065 |
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