Mutant IDH1 is required for IDH1 mutated tumor cell growth

Frequent somatic hotspot mutations in isocitrate dehydrogenase 1 (IDH1) have been identified in gliomas, acute myeloid leukemias, chondrosarcomas, and other cancers, providing a likely avenue for targeted cancer therapy. However, whether mutant IDH1 protein is required for maintaining IDH1 mutated t...

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Main Authors: Jin, Genglin, Pirozzi, Christopher J., Chen, Lee H., Lopez, Giselle Y., Duncan, Christopher G., Feng, Jie, Spasojevic, Ivan, Bigner, Darell D., He, Yiping, Yan, Hai
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2012
Assuntos:
Brief Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478455/
https://ncbi.nlm.nih.gov/pubmed/22885298
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