Disruption of wild type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas

Point mutations at Arg132 of the cytoplasmic NADP+-dependent isocitrate dehydrogenase 1 (IDH1) occur frequently in gliomas and result in a gain-of-function to produce the “oncometabolite” D-2-hydroxyglutarate (D-2HG). The mutated IDH1 allele is usually associated with a wild type IDH1 allele (hetero...

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Autors principals: Jin, Genglin, Reitman, Zachary J., Duncan, Chritopher G., Spasojevic, Ivan, Gooden, David M., Rasheed, B. Ahmed, Yang, Rui, Lopez, Giselle Y., He, Yiping, McLendon, Roger E., Bigner, Darell D., Yan, Hai
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548957/
https://ncbi.nlm.nih.gov/pubmed/23204232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2852
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