IDH1 mutation identified in human melanoma

Isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are enzymes which convert isocitrate to α-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+ to NADPH). IDH1/2 were recently identified as mutated in a large percentage of progressive gliomas. These...

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Autori principali: Lopez, Giselle Y., Reitman, Zachary J., Solomon, David, Waldman, Todd, Bigner, Darell D., McLendon, Roger E., Samuels, Yardena, Yan, Hai
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987603/
https://ncbi.nlm.nih.gov/pubmed/20603105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.06.125
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