Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression

IDH1 mutations occur in the majority of low-grade gliomas and lead to the production of the oncometabolite, D-2-hydroxyglutarate (D-2HG). To understand the effects of tumor-associated mutant IDH1 (IDH1-R132H) on both the neural stem cell (NSC) population and brain tumorigenesis, genetically faithful...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Pirozzi, Christopher J., Carpenter, Austin B., Waitkus, Matthew S., Wang, Catherine Y., Zhu, Huishan, Hansen, Landon J., Chen, Lee H., Greer, Paula K., Feng, Jie, Wang, Yu, Bock, Cheryl B., Fan, Ping, Spasojevic, Ivan, McLendon, Roger E., Bigner, Darell D., He, Yiping, Yan, Hai
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415422/
https://ncbi.nlm.nih.gov/pubmed/28148827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0485
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