Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression

IDH1 mutations occur in the majority of low-grade gliomas and lead to the production of the oncometabolite, D-2-hydroxyglutarate (D-2HG). To understand the effects of tumor-associated mutant IDH1 (IDH1-R132H) on both the neural stem cell (NSC) population and brain tumorigenesis, genetically faithful...

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Pubblicato in:Mol Cancer Res
Autori principali: Pirozzi, Christopher J., Carpenter, Austin B., Waitkus, Matthew S., Wang, Catherine Y., Zhu, Huishan, Hansen, Landon J., Chen, Lee H., Greer, Paula K., Feng, Jie, Wang, Yu, Bock, Cheryl B., Fan, Ping, Spasojevic, Ivan, McLendon, Roger E., Bigner, Darell D., He, Yiping, Yan, Hai
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415422/
https://ncbi.nlm.nih.gov/pubmed/28148827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0485
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