Adaptive evolution of the GDH2 allosteric domain promotes gliomagenesis by resolving IDH1(R132H) induced metabolic liabilities

Hot-spot mutations in the isocitrate dehydrogenase 1 (IDH1) gene occur in a number of human cancers and confer a neomorphic enzyme activity that catalyzes the conversion of α-ketoglutarate (αKG) to the oncometabolite D-(2)-hydroxyglutarate (D2HG). In malignant gliomas, IDH1(R132H) expression induces...

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保存先:
書誌詳細
出版年:Cancer Res
主要な著者: Waitkus, Matthew S., Pirozzi, Christopher J., Moure, Casey J., Diplas, Bill H., Hansen, Landon, Carpenter, Austin, Yang, Rui, Wang, Zhaohui, Ingram, Brian O., Karoly, Edward D., Mohney, Robert P., Spasojevic, Ivan, McLendon, Roger E., Friedman, Henry S., He, Yiping, Bigner, Darell D., Yan, Hai
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754242/
https://ncbi.nlm.nih.gov/pubmed/29097607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1352
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