Adaptive evolution of the GDH2 allosteric domain promotes gliomagenesis by resolving IDH1(R132H) induced metabolic liabilities

Hot-spot mutations in the isocitrate dehydrogenase 1 (IDH1) gene occur in a number of human cancers and confer a neomorphic enzyme activity that catalyzes the conversion of α-ketoglutarate (αKG) to the oncometabolite D-(2)-hydroxyglutarate (D2HG). In malignant gliomas, IDH1(R132H) expression induces...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Waitkus, Matthew S., Pirozzi, Christopher J., Moure, Casey J., Diplas, Bill H., Hansen, Landon, Carpenter, Austin, Yang, Rui, Wang, Zhaohui, Ingram, Brian O., Karoly, Edward D., Mohney, Robert P., Spasojevic, Ivan, McLendon, Roger E., Friedman, Henry S., He, Yiping, Bigner, Darell D., Yan, Hai
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754242/
https://ncbi.nlm.nih.gov/pubmed/29097607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1352
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