CRISPR editing of mutant IDH1 R132H induces a CpG methylation-low state in patient-derived glioma models of G-CIMP

Mutations in isocitrate dehydrogenases 1 and 2 (IDH) occur in the majority of WHO grade II and III gliomas. IDH1/2 active site mutations confer a neomorphic enzyme activity producing the oncometabolite D-2-hydroxyglutarate (D-2HG), which generates the glioma CpG island methylation phenotype (G-CIMP)...

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Gepubliceerd in:Mol Cancer Res
Hoofdauteurs: Moure, Casey J., Diplas, Bill H., Chen, Lee H., Yang, Rui, Pirozzi, Christopher J., Wang, Zhaohui, Spasojevic, Ivan, Waitkus, Matthew S., He, Yiping, Yan, Hai
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774824/
https://ncbi.nlm.nih.gov/pubmed/31292202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0309
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