Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression

IDH1 mutations occur in the majority of low-grade gliomas and lead to the production of the oncometabolite, D-2-hydroxyglutarate (D-2HG). To understand the effects of tumor-associated mutant IDH1 (IDH1-R132H) on both the neural stem cell (NSC) population and brain tumorigenesis, genetically faithful...

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Detaylı Bibliyografya
Yayımlandı:Mol Cancer Res
Asıl Yazarlar: Pirozzi, Christopher J., Carpenter, Austin B., Waitkus, Matthew S., Wang, Catherine Y., Zhu, Huishan, Hansen, Landon J., Chen, Lee H., Greer, Paula K., Feng, Jie, Wang, Yu, Bock, Cheryl B., Fan, Ping, Spasojevic, Ivan, McLendon, Roger E., Bigner, Darell D., He, Yiping, Yan, Hai
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415422/
https://ncbi.nlm.nih.gov/pubmed/28148827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0485
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