DIPG-12. CHARACTERIZING THE ROLE OF PPM1D MUTATIONS IN THE PATHOGENESIS OF DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs)

Diffuse Intrinsic Pontine Gliomas (DIPGs) are universally fatal. Effective treatments are desperately needed. DIPGs harbor histone K27M mutations (H3F3A or HIST1H3B) and also alterations that lead to growth factor receptor activation (such as PDGFRA amplification). We and others have found recurrent...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Khadka, Prasidda, Reitman, Zachary J, Buchan, Graham, Hartley, Rachel, Bear, Heather, Georgis, Yohanna, Jarmale, Spandana, Schoolcraft, Kathleen, Miller, Peter, Stiles, Charles D, Chowdhury, Dipanjan, Haas-Kogan, Daphne, Johannessen, Cory, Ebert, Benjamin L, Ligon, Keith L, Phoenix, Timothy, Beroukhim, Rameen, Bandopadhayay, Pratiti
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Diffuse Intrinsic Pontine Glioma (DIPG)
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477302/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.033
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