DIPG-53. CHARACTERIZING THE ROLE OF PPM1D MUTATIONS IN THE PATHOGENESIS OF DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGS)

INTRODUCTION: We have previously found that up to 15% of all DIPGs harbor mutations in PPM1D, resulting in the expression of an activated and truncated PPM1D (PPM1Dtr). Here we evaluate the mechanisms through which PPM1Dtr enhances glioma formation and identify its associated therapeutic vulnerabili...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Neuro Oncol
المؤلفون الرئيسيون: Khadka, Prasidda, Reitman, Zachary, Lu, Sophie, Buchan, Graham, Hartley, Rachel, Bear, Heather, Georgis, Yoahnna, Jarmale, Spandana, Schoolcraft, Kathleen, Miller, Peter, Gonzalez, Elizabeth, Gionet, Gabrielle, Qian, Kenin, Melanson, Randy, Keshishian, Hasmik, Carvalho, Diana, Condurat, Alexandra, Goodale, Amy, Abid, Tanaz, Piccioni, Federica, Chi, Susan, Carr, Steven, Haas-Kogan, Daphne, Ebert, Benjamin, Kieran, Mark, Jones, Chris, Ligon, Keith, Beroukhim, Rameen, Phoenix, Timothy, Bandopadhayay, Pratiti
التنسيق: Artigo
اللغة:Inglês
منشور في: Oxford University Press 2020
الموضوعات:
Diffuse Midline Glioma/DIPG
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715627/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.098
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