DIPG-53. CHARACTERIZING THE ROLE OF PPM1D MUTATIONS IN THE PATHOGENESIS OF DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGS)

INTRODUCTION: We have previously found that up to 15% of all DIPGs harbor mutations in PPM1D, resulting in the expression of an activated and truncated PPM1D (PPM1Dtr). Here we evaluate the mechanisms through which PPM1Dtr enhances glioma formation and identify its associated therapeutic vulnerabili...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Neuro Oncol
Main Authors: Khadka, Prasidda, Reitman, Zachary, Lu, Sophie, Buchan, Graham, Hartley, Rachel, Bear, Heather, Georgis, Yoahnna, Jarmale, Spandana, Schoolcraft, Kathleen, Miller, Peter, Gonzalez, Elizabeth, Gionet, Gabrielle, Qian, Kenin, Melanson, Randy, Keshishian, Hasmik, Carvalho, Diana, Condurat, Alexandra, Goodale, Amy, Abid, Tanaz, Piccioni, Federica, Chi, Susan, Carr, Steven, Haas-Kogan, Daphne, Ebert, Benjamin, Kieran, Mark, Jones, Chris, Ligon, Keith, Beroukhim, Rameen, Phoenix, Timothy, Bandopadhayay, Pratiti
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2020
נושאים:
Diffuse Midline Glioma/DIPG
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715627/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.098
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