OMRT-6. Optimizing MDM2 inhibition for the treatment of high-grade glioma

Over 80% of high-grade gliomas have alterations in members of the p53 pathway, a central regulator of cell cycle progression and apoptosis that becomes activated in response to cellular stress and DNA damage. For tumors that retain wild-type p53, pathway deregulation frequently occurs through the am...

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Veröffentlicht in:Neurooncol Adv
Hauptverfasser: Rendo, Veronica, Lupien, Leslie, Khuu, Nicholas, Pelton, Kristine, Lu, Sophie, Khadka, Prasidda, Langhnoja, Jaldeep, Phoenix, Timothy, Ligon, Keith, Bandopadhayay, Pratiti, Beroukhim, Rameen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
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Supplement Abstracts
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8255430/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab070.031
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