DIPG-12. CHARACTERIZING THE ROLE OF PPM1D MUTATIONS IN THE PATHOGENESIS OF DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs)

Diffuse Intrinsic Pontine Gliomas (DIPGs) are universally fatal. Effective treatments are desperately needed. DIPGs harbor histone K27M mutations (H3F3A or HIST1H3B) and also alterations that lead to growth factor receptor activation (such as PDGFRA amplification). We and others have found recurrent...

詳細記述

保存先:
書誌詳細
出版年:Neuro Oncol
主要な著者: Khadka, Prasidda, Reitman, Zachary J, Buchan, Graham, Hartley, Rachel, Bear, Heather, Georgis, Yohanna, Jarmale, Spandana, Schoolcraft, Kathleen, Miller, Peter, Stiles, Charles D, Chowdhury, Dipanjan, Haas-Kogan, Daphne, Johannessen, Cory, Ebert, Benjamin L, Ligon, Keith L, Phoenix, Timothy, Beroukhim, Rameen, Bandopadhayay, Pratiti
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2019
主題:
Diffuse Intrinsic Pontine Glioma (DIPG)
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477302/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.033
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