Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

Point mutations of the NADP(+)-dependent isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) occur early in the pathogenesis of gliomas. When mutated, IDH1 and IDH2 gain the ability to produce the metabolite (R)-2-hydroxyglutarate (2HG), but the downstream effects of mutant IDH1 and IDH2 proteins or o...

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Main Authors: Reitman, Zachary J., Jin, Genglin, Karoly, Edward D., Spasojevic, Ivan, Yang, Jian, Kinzler, Kenneth W., He, Yiping, Bigner, Darell D., Vogelstein, Bert, Yan, Hai
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044380/
https://ncbi.nlm.nih.gov/pubmed/21289278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019393108
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