ACTR-31. PHASE 1 STUDY OF AG-881, AN INHIBITOR OF MUTANT IDH1 AND IDH2: RESULTS FROM THE RECURRENT/PROGRESSIVE GLIOMA POPULATION

INTRODUCTION: Isocitrate dehydrogenase 1 and 2 mutations (mIDH1/2) occur in >70% of low-grade gliomas and secondary glioblastomas, and lead to genetic and epigenetic dysregulation, promoting tumorigenesis. AG-881 is an oral, potent, brain-penetrant inhibitor of mIDH1/2 under phase 1 clinical eval...

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Publicado no:Neuro Oncol
Main Authors: Mellinghoff, Ingo, Penas-Prado, Marta, Peters, Katherine, Cloughesy, Timothy, Burris, Howard, Maher, Elizabeth, Janku, Filip, Cote, Gregory, De La Fuente, Macarena, Clarke, Jennifer, Steelman, Lori, Le, Kha, Xu, Huansheng, Sonderfan, Alison, Hummel, Diana, Schoenfeld, Steven, Yen, Katharine, Pandya, Shuchi, Wen, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216186/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.064
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