Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate

Monoallelic point mutations in the gene encoding the cytosolic, NADP(+)-dependent enzyme isocitrate dehydrogenase 1 (IDH1) cause increased production of the oncometabolite 2-hydroxyglutarate (2-HG) in multiple cancers. Most IDH1 mutant tumors retain one wildtype (WT) IDH1 allele. Several studies hav...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dexter, Joseph P., Ward, Patrick S., Dasgupta, Tathagata, Hosios, Aaron M., Gunawardena, Jeremy, Vander Heiden, Matthew G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311528/
https://ncbi.nlm.nih.gov/pubmed/30381394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004278
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