Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate

Monoallelic point mutations in the gene encoding the cytosolic, NADP(+)-dependent enzyme isocitrate dehydrogenase 1 (IDH1) cause increased production of the oncometabolite 2-hydroxyglutarate (2-HG) in multiple cancers. Most IDH1 mutant tumors retain one wildtype (WT) IDH1 allele. Several studies hav...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Dexter, Joseph P., Ward, Patrick S., Dasgupta, Tathagata, Hosios, Aaron M., Gunawardena, Jeremy, Vander Heiden, Matthew G.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2018
Предметы:
Metabolism
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311528/
https://ncbi.nlm.nih.gov/pubmed/30381394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004278
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы