লোডিং...

Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma

PURPOSE: Mutations in the IDH1 and IDH2 (IDH1/2) genes occur in ~20% of intrahepatic cholangiocarcinoma (ICC) and lead to accumulation of 2-hydroxyglutarate (2HG) in the tumor tissue. However, it remains unknown whether IDH1/2 mutations can lead to high levels of 2HG circulating in the blood and whe...

সম্পূর্ণ বিবরণ

সংরক্ষণ করুন:
গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Borger, Darrell R., Goyal, Lipika, Yau, Thomas, Poon, Ronnie T., Ancukiewicz, Marek, Deshpande, Vikram, Christiani, David C., Liebman, Hannah M., Yang, Hua, Kim, Hyeryun, Yen, Katharine, Faris, Jason E., Iafrate, A. John, Kwak, Eunice L., Clark, Jeffrey W., Allen, Jill N., Blaszkowsky, Lawrence S., Murphy, Janet E., Saha, Supriya K., Hong, Theodore S., Wo, Jennifer Y., Ferrone, Cristina R., Tanabe, Kenneth K., Bardeesy, Nabeel, Straley, Kimberly S., Agresta, Sam, Schenkein, David P., Ellisen, Leif W., Ryan, David P., Zhu, Andrew X.
বিন্যাস: Artigo
ভাষা:Inglês
প্রকাশিত: 2014
বিষয়গুলি:
অনলাইন ব্যবহার করুন:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107454/
https://ncbi.nlm.nih.gov/pubmed/24478380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2649
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