Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation

The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH), and isocitrate dehydrogenase (IDH) mutations in human cancers has rekindled the idea that altered cellular metabolism can transform cells. Inactivating SDH and FH mutations cause the accumulation of succinate and fumarate,...

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Autors principals: Koivunen, Peppi, Lee, Sungwoo, Duncan, Christopher G., Lopez, Giselle, Lu, Gang, Ramkissoon, Shakti, Losman, Julie A., Joensuu, Päivi, Bergmann, Ulrich, Gross, Stefan, Travins, Jeremy, Weiss, Samuel, Looper, Ryan, Ligon, Keith L., Verhaak, Roel G.W., Yan, Hai, Kaelin, William G.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656605/
https://ncbi.nlm.nih.gov/pubmed/22343896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10898
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