Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

The three EglN prolyl hydroxylases (EglN1, EglN2, and EglN3) regulate the stability of the HIF transcription factor. We recently showed that loss of EglN2, however, also leads to down-regulation of Cyclin D1 and decreased cell proliferation in a HIF-independent manner. Here we report that EglN2 can...

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Autors principals: Zheng, Xingnan, Zhai, Bo, Koivunen, Peppi, Shin, Sandra J., Lu, Gang, Liu, Jiayun, Geisen, Christoph, Chakraborty, Abhishek A., Moslehi, Javid J., Smalley, David M., Wei, Xin, Chen, Xian, Chen, Zhengming, Beres, Justine M., Zhang, Jing, Tsao, Jen Lan, Brenner, Mitchell C., Zhang, Yuqing, Fan, Cheng, DePinho, Ronald A., Paik, Jihye, Gygi, Steven P., Kaelin, William G., Zhang, Qing
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4083087/
https://ncbi.nlm.nih.gov/pubmed/24990963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.242131.114
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