Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase

SUMMARY: 2-Oxoglutarate-dependent dioxygenases, including the EglN prolyl hydroxylases that regulate HIF, can be inhibited with drug-like molecules. EglN2 is estrogen-inducible in breast carcinoma cells and the lone Drosophila EglN interacts genetically with Cyclin D1. Although EglN2 is a non-essent...

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Main Authors: Zhang, Qing, Gu, Jinming, Li, Lianjie, Liu, Jiayun, Luo, Biao, Cheung, Hiu-Wing, Boehm, Jesse S., Ni, Min, Geisen, Christoph, Root, David E., Polyak, Kornelia, Brown, Myles, Richardson, Andrea L., Hahn, William C., Kaelin, William G., Bommi-Reddy, Archana
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788761/
https://ncbi.nlm.nih.gov/pubmed/19878873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.09.029
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