EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance

Despite the discovery of the oxygen-sensitive regulation of HIFα by the von Hippel–Lindau (VHL) protein, the mechanisms underlying the complex genotype/phenotype correlations in VHL disease remain unknown. Some germline VHL mutations cause familial pheochromocytoma and encode proteins that preserve...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Li, Shuijie, Rodriguez, Javier, Li, Wenyu, Bullova, Petra, Fell, Stuart M., Surova, Olga, Westerlund, Isabelle, Topcic, Danijal, Bergsland, Maria, Stenman, Adam, Muhr, Jonas, Nistér, Monica, Holmberg, Johan, Juhlin, C. Christofer, Larsson, Catharina, von Kriegsheim, Alex, Kaelin, William G., Schlisio, Susanne
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2019
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PNAS Plus
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708352/
https://ncbi.nlm.nih.gov/pubmed/31375625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900748116
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