EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance

Despite the discovery of the oxygen-sensitive regulation of HIFα by the von Hippel–Lindau (VHL) protein, the mechanisms underlying the complex genotype/phenotype correlations in VHL disease remain unknown. Some germline VHL mutations cause familial pheochromocytoma and encode proteins that preserve...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Li, Shuijie, Rodriguez, Javier, Li, Wenyu, Bullova, Petra, Fell, Stuart M., Surova, Olga, Westerlund, Isabelle, Topcic, Danijal, Bergsland, Maria, Stenman, Adam, Muhr, Jonas, Nistér, Monica, Holmberg, Johan, Juhlin, C. Christofer, Larsson, Catharina, von Kriegsheim, Alex, Kaelin, William G., Schlisio, Susanne
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2019
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708352/
https://ncbi.nlm.nih.gov/pubmed/31375625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900748116
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