EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance

Despite the discovery of the oxygen-sensitive regulation of HIFα by the von Hippel–Lindau (VHL) protein, the mechanisms underlying the complex genotype/phenotype correlations in VHL disease remain unknown. Some germline VHL mutations cause familial pheochromocytoma and encode proteins that preserve...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Li, Shuijie, Rodriguez, Javier, Li, Wenyu, Bullova, Petra, Fell, Stuart M., Surova, Olga, Westerlund, Isabelle, Topcic, Danijal, Bergsland, Maria, Stenman, Adam, Muhr, Jonas, Nistér, Monica, Holmberg, Johan, Juhlin, C. Christofer, Larsson, Catharina, von Kriegsheim, Alex, Kaelin, William G., Schlisio, Susanne
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708352/
https://ncbi.nlm.nih.gov/pubmed/31375625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900748116
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi