(R)-2-Hydroxyglutarate is Sufficient to Promote Leukemogenesis and its Effects are Reversible

IDH1 and IDH2 (Isocitrate Dehydrogenase 1 and 2) mutants are common in several cancers, including leukemias, and overproduce the (R)-enantiomer of 2-hydroxyglutarate [(R)-2-HG]. Elucidating the role of IDH mutations and (R)-2-HG in leukemogenesis has been hampered by a lack of appropriate cell-based...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Losman, Julie-Aurore, Looper, Ryan, Koivunen, Peppi, Lee, Sungwoo, Schneider, Rebekka K., McMahon, Christine, Cowley, Glenn, Root, David, Ebert, Benjamin L., Kaelin, William G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836459/
https://ncbi.nlm.nih.gov/pubmed/23393090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1231677
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi