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Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia
Despite extensive insights into the underlying genetics and biology of acute myeloid leukemia (AML), overall survival remains poor and new therapies are needed. We found that casein kinase 1 α (Csnk1a1), a serine-threonine kinase, is essential for AML cell survival in vivo. Normal hematopoietic stem...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Rockefeller University Press
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3978274/ https://ncbi.nlm.nih.gov/pubmed/24616378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131033 |
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