Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia

Despite extensive insights into the underlying genetics and biology of acute myeloid leukemia (AML), overall survival remains poor and new therapies are needed. We found that casein kinase 1 α (Csnk1a1), a serine-threonine kinase, is essential for AML cell survival in vivo. Normal hematopoietic stem...

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Bibliographic Details
Main Authors: Järås, Marcus, Miller, Peter G., Chu, Lisa P., Puram, Rishi V., Fink, Emma C., Schneider, Rebekka K., Al-Shahrour, Fatima, Peña, Pablo, Breyfogle, L. Jordan, Hartwell, Kimberly A., McConkey, Marie E., Cowley, Glenn S., Root, David E., Kharas, Michael G., Mullally, Ann, Ebert, Benjamin L.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2014
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Brief Definitive Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978274/
https://ncbi.nlm.nih.gov/pubmed/24616378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131033
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