In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

We used an in vivo short hairpin RNA (shRNA) screening approach to identify genes that are essential for MLL-AF9 acute myeloid leukemia (AML). We found that Integrin Beta 3 (Itgb3) is essential for murine leukemia cells in vivo, and for human leukemia cells in xenotransplantation studies. In leukemi...

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Main Authors: Miller, Peter G., Al-Shahrour, Fatima, Hartwell, Kimberly A., Chu, Lisa P., Järås, Marcus, Puram, Rishi V., Puissant, Alexandre, Callahan, Kevin P., Ashton, John, McConkey, Marie E., Poveromo, Luke P., Cowley, Glenn S., Kharas, Michael G., Labelle, Myriam, Shterental, Sebastian, Fujisaki, Joji, Silberstein, Lev, Alexe, Gabriela, Al-Hajj, Muhammad A., Shelton, Christopher A., Armstrong, Scott A., Root, David E., Scadden, David T., Hynes, Richard O., Mukherjee, Siddhartha, Stegmaier, Kimberly, Jordan, Craig T., Ebert, Benjamin L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746037/
https://ncbi.nlm.nih.gov/pubmed/23770013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.05.004
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