Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis

Chronic kidney disease is characterized by interstitial fibrosis and proliferation of scar-secreting myofibroblasts, ultimately leading to end-stage renal disease. The hedgehog (Hh) pathway transcriptional effectors GLI1 and GLI2 are expressed in myofibroblast progenitors; however, the role of these...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Kramann, Rafael, Fleig, Susanne V., Schneider, Rebekka K., Fabian, Steven L., DiRocco, Derek P., Maarouf, Omar, Wongboonsin, Janewit, Ikeda, Yoichiro, Heckl, Dirk, Chang, Steven L., Rennke, Helmut G., Waikar, Sushrut S., Humphreys, Benjamin D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563736/
https://ncbi.nlm.nih.gov/pubmed/26193634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74929
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