Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis

Chronic kidney disease is characterized by interstitial fibrosis and proliferation of scar-secreting myofibroblasts, ultimately leading to end-stage renal disease. The hedgehog (Hh) pathway transcriptional effectors GLI1 and GLI2 are expressed in myofibroblast progenitors; however, the role of these...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Kramann, Rafael, Fleig, Susanne V., Schneider, Rebekka K., Fabian, Steven L., DiRocco, Derek P., Maarouf, Omar, Wongboonsin, Janewit, Ikeda, Yoichiro, Heckl, Dirk, Chang, Steven L., Rennke, Helmut G., Waikar, Sushrut S., Humphreys, Benjamin D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563736/
https://ncbi.nlm.nih.gov/pubmed/26193634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74929
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