Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the ubiquitination of casein kinase 1A1 (CK1α) by the CRL4(CRBN) E3 ubiquitin ligase, resulting in CK1α degradation. CK1α is encode...

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Xehetasun bibliografikoak
Argitaratua izan da:Nature
Egile Nagusiak: Krönke, Jan, Fink, Emma C., Hollenbach, Paul W., MacBeth, Kyle J., Hurst, Slater N., Udeshi, Namrata D., Chamberlain, Philip P., Mani, D.R., Man, Hon Wah, Gandhi, Anita K., Svinkina, Tanya, Schneider, Rebekka K., McConkey, Marie, Järås, Marcus, Griffiths, Elizabeth, Wetzler, Meir, Bullinger, Lars, Cathers, Brian E., Carr, Steven A., Chopra, Rajesh, Ebert, Benjamin L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853910/
https://ncbi.nlm.nih.gov/pubmed/26131937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14610
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