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Lenalidomide induces degradation of IKZF1 and IKZF3
Lenalidomide and its analogs, thalidomide and pomalidomide, specifically inhibit growth of mature B-cell lymphomas, including multiple myeloma, and induce interleukin-2 (IL-2) release from T cells. We recently found that this results from activation of the CRBN-CRL4 E3 ubiquitin ligase to degrade th...
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| Publicado en: | Oncoimmunology |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4292522/ https://ncbi.nlm.nih.gov/pubmed/25610725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.941742 |
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