RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation

Ikaros family zinc finger protein 1 and 3 (IKZF1 and IKZF3) are transcription factors that promote multiple myeloma (MM) proliferation. The immunomodulatory imide drug (IMiD) lenalidomide promotes myeloma cell death via Cereblon (CRBN)-dependent ubiquitylation and proteasome-dependent degradation of...

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Publicado no:Leukemia
Main Authors: Zhou, Nan, Gutierrez-Uzquiza, Alvaro, Zheng, Xiang Yu, Chang, Renxu, Vogl, Dan T., Garfall, Alfred L., Bernabei, Luca, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Illendula, Anuradha, Bushweller, John H., Busino, Luca
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687534/
https://ncbi.nlm.nih.gov/pubmed/30760870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0403-2
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